The Louisiana Tech Bulldogs of the WAC and the Southern Miss Golden Eagles of Conference USA have scheduled a 4-game football series beginning in 2010. The teams will face off in Ruston, LA on September 25, 2010 and in Hattiesburg, MS on September 3, 2011.

The Bulldogs and Eagles will not play each other in 2012. They will meet September 14, 2013 in Ruston and September 6, 2014 in Hattiesburg.

Southern Miss and Louisiana Tech have met 42 times since 1935. The Golden Eagles lead the overall series 29-13. The teams last played in 1992 and Southern Miss won 16-13.