After falling behind 10-0, the Saints kicked two field goals to go into halftime trailing only 10-6. The Saints then recovered their surprise onside kickoff and scored to take a 13-10 lead. Joseph Addai would later score for the Colts making it 17-13. It would be the last points Indianapolis would score.
New Orleans added a field goal and a Jeremy Shockey touchdown reception to take a 24-17 lead. Late in the fourth quarter, Tracy Porter intercepted a Peyton Manning pass and returned it 74 yards for a touchdown and iced the game for the Saints.