2010 Penn State Nittany Lions Football ScheduleFinal Record: 7-6, 4-4 (Big Ten) | ||||
| Date | Opponent | Result | Tickets | |
| Saturday Sep. 4 |  | Youngstown State Penguins Beaver Stadium, University Park, PA | Won 44-14 | |
| Saturday Sep. 11 |  | at Alabama Crimson Tide Bryant-Denny Stadium, Tuscaloosa, AL | Lost 24-3 | |
| Saturday Sep. 18 |  | Kent State Golden Flashes Beaver Stadium, University Park, PA | Won 24-0 | |
| Saturday Sep. 25 |  | Temple Owls Beaver Stadium, University Park, PA | Won 22-13 | |
| Saturday Oct. 2 |  | at Iowa Hawkeyes Kinnick Stadium, Iowa City, IA | Lost 24-3 | |
| Saturday Oct. 9 |  | Illinois Fighting Illini Beaver Stadium, University Park, PA | Lost 33-13 | |
| Saturday Oct. 16 | Open Date | |||
| Saturday Oct. 23 |  | at Minnesota Golden Gophers TCF Bank Stadium, Minneapolis, MN | Won 33-21 | |
| Saturday Oct. 30 |  | Michigan Wolverines Beaver Stadium, University Park, PA | Won 41-31 | |
| Saturday Nov. 6 |  | Northwestern Wildcats Beaver Stadium, University Park, PA | Won 35-21 | |
| Saturday Nov. 13 |  | at Ohio State Buckeyes Ohio Stadium, Columbus, OH | Lost 38-14 | |
| Saturday Nov. 20 |  | Indiana Hoosiers FedEx Field, Landover, MD | Won 41-24 | |
| Saturday Nov. 27 |  | Michigan State Spartans Beaver Stadium, University Park, PA | Lost 28-22 | |
| 2011 Outback Bowl | ||||
| Saturday Jan. 1 |  | Florida Gators Raymond James Stadium, Tampa, FL | Lost 37-24 | |
