 | East Carolina Pirates | |
2010 East Carolina Pirates Football ScheduleFinal Record: 6-7, 5-3 (C-USA) | |||
| Date/Time | Opponent | Result | Tickets |
| Sun. Sept. 5 2:00 p.m. ET |  Tulsa | Won 51-49 | --- |
| Sat. Sept. 11 12:00 p.m. ET |  Memphis | Won 49-27 | --- |
| Sat. Sept. 18 1:30 p.m. ET |  at Virginia Tech | Lost 49-27 | --- |
| Sat. Sept. 25 | Open Date | --- | --- |
| Sat. Oct. 2 3:30 p.m. ET |  at North Carolina | Lost 42-17 | --- |
| Sat. Oct. 9 7:30 p.m. ET |  at Southern Miss | Won 44-43 | --- |
| Sat. Oct. 16 12:00 p.m. ET |  NC State | Won 33-27 (OT) | --- |
| Sat. Oct. 23 4:00 p.m. ET |  Marshall | Won 37-10 | --- |
| Sat. Oct. 30 3:30 p.m. ET |  at UCF | Lost 49-35 | --- |
| Sat. Nov. 6 3:30 p.m. ET |  Navy | Lost 76-35 | --- |
| Thu. Nov. 11 8:00 p.m. ET |  at UAB | Won 54-42 | --- |
| Sat. Nov. 20 1:00 p.m. ET |  at Rice | Lost 62-38 | --- |
| Fri. Nov. 26 2:00 p.m. ET |  SMU | Lost 45-38 (OT) | --- |
| 2010 Military Bowl at Washington, DC (RFK Stadium) | |||
| Wed. Dec. 29 2:30 p.m. ET |  Maryland | Lost 51-20 | --- |
