 | Wyoming Cowboys | |
| 2010 Wyoming Cowboys Football Schedule Final Record: 3-9, 1-7 (MWC) | |||
| Date/Time | Opponent | Result | Tickets |
| Sat. Sept. 4 7:00 p.m. MT |  Southern Utah | Won 28-20 | --- |
| Sat. Sept. 11 5:00 p.m. MT |  at Texas | Lost 34-7 | --- |
| Sat. Sept. 18 6:00 p.m. MT |  Boise State | Lost 51-6 | --- |
| Sat. Sept. 25 12:00 p.m. MT |  Air Force | Lost 20-14 | --- |
| Sat. Oct. 2 5:00 p.m. MT |  at Toledo | Won 20-15 | --- |
| Sat. Oct. 9 1:30 p.m. MT |  at TCU | Lost 45-0 | --- |
| Sat. Oct. 16 4:00 p.m. MT |  Utah | Lost 30-6 | --- |
| Sat. Oct. 23 12:00 p.m. MT |  at BYU | Lost 25-20 | --- |
| Sat. Oct. 30 12:00 p.m. MT |  San Diego State | Lost 48-38 | --- |
| Sat. Nov. 6 4:00 p.m. MT |  at New Mexico | Lost 34-31 | --- |
| Sat. Nov. 13 8:00 p.m. MT |  at UNLV | Lost 42-16 | --- |
| Sat. Nov. 20 12:00 p.m. MT |  Colorado State | Won 44-0 | --- |
