 | Western Kentucky Hilltoppers | |
2010 Western Kentucky Hilltoppers Football ScheduleFinal Record: 2-10, 2-6 (Sun Belt) | |||
| Date/Time | Opponent | Result | Tickets |
| Sat. Sept. 4 6:00 p.m. CT |  at Nebraska | Lost 49-10 | --- |
| Sat. Sept. 11 6:30 p.m. CT |  at Kentucky | Lost 63-28 | --- |
| Sat. Sept. 18 4:00 p.m. CT |  Indiana | Lost 38-21 | --- |
| Sat. Sept. 25 6:05 p.m. CT |  at USF | Lost 24-12 | --- |
| Sat. Oct. 2 | Open Date | --- | --- |
| Sat. Oct. 9 2:30 p.m. CT |  at Florida International | Lost 28-21 | --- |
| Sat. Oct. 16 6:00 p.m. CT |  ULM | Lost 35-30 | --- |
| Sat. Oct. 23 4:00 p.m. CT |  at UL Lafayette | Won 54-21 | --- |
| Sat. Oct. 30 2:00 p.m. CT |  North Texas | Lost 33-6 | --- |
| Sat. Nov. 6 3:30 p.m. CT |  Florida Atlantic | Lost 17-16 | --- |
| Sat. Nov. 13 2:00 p.m. CT |  at Arkansas State | Won 36-35 (OT) | --- |
| Sat. Nov. 20 3:30 p.m. CT |  Middle Tennessee | Lost 27-26 | --- |
| Sat. Nov. 27 2:30 p.m. CT |  at Troy | Lost 28-14 | --- |
