| Houston Cougars | ||
2012 Houston Cougars Football ScheduleFinal Record: 5-7, 4-4 (C-USA) | ||||
| Date | Opponent | Time/TV | Tickets | |
| Saturday Sept. 1 | Texas State Bobcats Robertson Stadium, Houston, TX | Lost 30-13 | --- | |
| Saturday Sept. 8 | Louisiana Tech Bulldogs Robertson Stadium, Houston, TX | Lost 56-49 | --- | |
| Saturday Sept. 15 | at UCLA Bruins Rose Bowl, Los Angeles, CA | Lost 37-6 | --- | |
| Saturday Sept. 22 | --- | Open Date | --- | --- |
| Saturday Sept. 29 | Rice Owls Reliant Stadium, Houston, TX | Won 35-14 | --- | |
| Saturday Oct. 6 | North Texas Mean Green Robertson Stadium, Houston, TX | Won 44-21 | --- | |
| Saturday Oct. 13 | UAB Blazers Robertson Stadium, Houston, TX | Won 39-17 | --- | |
| Thursday Oct. 18 | at SMU Mustangs Gerald J. Ford Stadium, Dallas, TX | Lost 72-42 | --- | |
| Saturday Oct. 27 | UTEP Miners Robertson Stadium, Houston, TX | Won 45-35 | --- | |
| Saturday Nov. 3 | at East Carolina Pirates Dowdy-Ficklen Stadium, Greenville, NC | Lost 48-28 | --- | |
| Saturday Nov. 10 | Tulsa Golden Hurricane (HC) Robertson Stadium, Houston, TX | Lost 41-7 | --- | |
| Saturday Nov. 17 | at Marshall Thundering Herd Joan C. Edwards Stadium, Huntington, WV | Lost 44-41 | --- | |
| Saturday Nov. 24 | Tulane Green Wave Robertson Stadium, Houston, TX | Won 40-17 | --- | |