2015 Louisville Cardinals Football ScheduleRecord: 8-5, 5-3 (ACC) | ||||
| Date | Opponent | Time/TV | Tickets | |
| Saturday Sep. 5 |  | Auburn Tigers Georgia Dome, Atlanta, GA | Lost 31-24 | |
| Saturday Sep. 12 |  | Houston Cougars Papa John's Cardinal Stadium, Louisville, KY | Lost 34-31 | |
| Thursday Sep. 17 |  | Clemson Tigers Papa John's Cardinal Stadium, Louisville, KY | Lost 20-17 | |
| Saturday Sep. 26 |  | Samford Bulldogs Papa John's Cardinal Stadium, Louisville, KY | Won 45-3 | |
| Saturday Oct. 3 |  | at NC State Wolfpack Carter-Finley Stadium, Raleigh, NC | Won 20-13 | |
| Saturday Oct. 10 | Open Date | |||
| Saturday Oct. 17 |  | at Florida State Seminoles Doak Campbell Stadium, Tallahassee, FL | Lost 41-21 | |
| Saturday Oct. 24 |  | Boston College Eagles (HC) Papa John's Cardinal Stadium, Louisville, KY | Won 17-14 | |
| Friday Oct. 30 |  | at Wake Forest Demon Deacons BB&T Field, Winston-Salem, NC | Won 20-19 | |
| Saturday Nov. 7 |  | Syracuse Orange Papa John's Cardinal Stadium, Louisville, KY | Won 41-17 | |
| Saturday Nov. 14 |  | Virginia Cavaliers Papa John's Cardinal Stadium, Louisville, KY | Won 38-31 | |
| Saturday Nov. 21 |  | at Pittsburgh Panthers Heinz Field, Pittsburgh, PA | Lost 45-34 | |
| Saturday Nov. 28 |  | at Kentucky Wildcats Commonwealth Stadium, Lexington, KY | Won 38-24 | |
| 2015 Franklin American Mortgage Music City Bowl | ||||
| Wednesday Dec. 30 |  | Texas A&M Aggies Nissan Stadium, Nashville, TN | Won 27-21 | |
