 | Buffalo Bills | |
2008 Buffalo Bills Football ScheduleFinal Record: 7-9, 4-2 (AFC East) | ||||
| Date | Opponent | Result | Tickets | |
| Sunday Sept. 7 |  | Seattle Seahawks Ralph Wilson Stadium, Orchard Park, NY | Won 34-10 | --- |
| Sunday Sept. 14 |  | at Jacksonville Jaguars Jacksonville Municipal Stadium, Jacksonville, FL | Won 20-16 | --- |
| Sunday Sept. 21 |  | Oakland Raiders Ralph Wilson Stadium, Orchard Park, NY | Won 24-23 | --- |
| Sunday Sept. 28 |  | at St. Louis Rams Edward Jones Dome, St. Louis, MO | Won 31-14 | --- |
| Sunday Oct. 5 |  | at Arizona Cardinals University of Phoenix Stadium, Glendale, AZ | Lost 41-17 | --- |
| Sunday Oct. 12 | --- | BYE | --- | --- |
| Sunday Oct. 19 |  | San Diego Chargers Ralph Wilson Stadium, Orchard Park, NY | Won 23-14 | --- |
| Sunday Oct. 26 |  | at Miami Dolphins Dolphin Stadium, Miami Gardens, FL | Lost 25-16 | --- |
| Sunday Nov. 2 |  | New York Jets Ralph Wilson Stadium, Orchard Park, NY | Lost 26-17 | --- |
| Sunday Nov. 9 |  | at New England Patriots Gillette Stadium, Foxborough, MA | Lost 20-10 | --- |
| Monday Nov. 17 |  | Cleveland Browns Ralph Wilson Stadium, Orchard Park, NY | Lost 29-27 | --- |
| Sunday Nov. 23 |  | at Kansas City Chiefs Arrowhead Stadium, Kansas City, MO | Won 54-31 | --- |
| Sunday Nov. 30 |  | San Francisco 49ers Ralph Wilson Stadium, Orchard Park, NY | Lost 10-3 | --- |
| Sunday Dec. 7 | | Miami Dolphins Rogers Centre, Toronto, Canada | Lost 16-3 | --- |
| Sunday Dec. 14 | | at New York Jets Giants Stadium, East Rutherford, NJ | Lost 31-27 | --- |
| Sunday Dec. 21 |  | at Denver Broncos Invesco Field at Mile High, Denver, CO | Won 30-23 | --- |
| Sunday Dec. 28 | | New England Patriots Ralph Wilson Stadium, Orchard Park, NY | Lost 13-0 | --- |
