| New England Patriots | ||
2008 New England Football ScheduleFinal Record: 11-5, 4-2 (AFC East) | ||||
| Date | Opponent | Result | Tickets | |
| Sunday Sept. 7 | Kansas City Chiefs Gillette Stadium, Foxborough, MA | Won 17-10 | --- | |
| Sunday Sept. 14 | at New York Jets Giants Stadium, East Rutherford, NJ | Won 19-10 | --- | |
| Sunday Sept. 21 | Miami Dolphins Gillette Stadium, Foxborough, MA | Lost 38-13 | --- | |
| Sunday Sept. 28 | --- | BYE | --- | --- |
| Sunday Oct. 5 | at San Francisco 49ers Candlestick Park, San Francisco, CA | Won 30-21 | --- | |
| Sunday Oct. 12 | at San Diego Chargers Qualcomm Stadium, San Diego, CA | Lost 30-10 | --- | |
| Monday Oct. 20 | Denver Broncos Gillette Stadium, Foxborough, MA | Won 41-7 | --- | |
| Sunday Oct. 26 | St. Louis Rams Gillette Stadium, Foxborough, MA | Won 23-16 | --- | |
| Sunday Nov. 2 | at Indianapolis Colts Lucas Oil Stadium, Indianapolis, IN | Lost 18-15 | --- | |
| Sunday Nov. 9 | Buffalo Bills Gillette Stadium, Foxborough, MA | Won 20-10 | --- | |
| Thursday Nov. 13 | New York Jets Gillette Stadium, Foxborough, MA | Lost 34-31 | --- | |
| Sunday Nov. 23 | at Miami Dolphins Dolphin Stadium, Miami Gardens, FL | Won 48-28 | --- | |
| Sunday Nov. 30 | Pittsburgh Steelers Gillette Stadium, Foxborough, MA | Lost 33-10 | --- | |
| Sunday Dec. 7 | at Seattle Seahawks Qwest Field, Seattle, WA | Won 24-21 | --- | |
| Sunday Dec. 14 | at Oakland Raiders Oakland–Alameda County Coliseum, Oakland, CA | Won 49-26 | --- | |
| Sunday Dec. 21 | Arizona Cardinals Gillette Stadium, Foxborough, MA | Won 47-7 | --- | |
| Sunday Dec. 28 | at Buffalo Bills Ralph Wilson Stadium, Orchard Park, NY | Won 13-0 | --- | |