 | San Francisco 49ers | |
2008 San Francisco 49ers Football ScheduleFinal Record: 7-9, 3-3 (NFC West) | |||
| Date/Time | Opponent | Result | Tickets |
| Sun. Sept. 7 |  Arizona Cardinals | Lost 23-13 | --- |
| Sun. Sept. 14 |  at Seattle Seahawks | Won 33-30 | --- |
| Sun. Sept. 21 |  Detroit Lions | Won 31-13 | --- |
| Sun. Sept. 28 |  at New Orleans Saints | Lost 31-17 | --- |
| Sun. Oct. 5 |  New England Patriots | Lost 30-21 | --- |
| Sun. Oct. 12 |  Philadelphia Eagles | Lost 40-26 | --- |
| Sun. Oct. 19 |  at New York Giants | Lost 29-17 | --- |
| Sun. Oct. 26 | Seattle Seahawks | Lost 34-13 | --- |
| Sun. Nov. 2 | Bye Week | --- | --- |
| Mon. Nov. 10 | at Arizona Cardinals | Lost 29-24 | --- |
| Sun. Nov. 16 |  St. Louis Rams | Won 35-16 | --- |
| Sun. Nov. 23 |  at Dallas Cowboys | Lost 35-22 | --- |
| Sun. Nov. 30 |  at Buffalo Bills | Won 10-3 | --- |
| Sun. Dec. 7 |  New York Jets | Won 24-14 | --- |
| Sun. Dec. 14 |  at Miami Dolphins | Lost 14-9 | --- |
| Sun. Dec. 21 | at St. Louis Rams | Won 17-16 | --- |
| Sun. Dec. 28 |  Washington Redskins | Won 27-24 | --- |
