| San Francisco 49ers | ||
2008 San Francisco 49ers Football ScheduleFinal Record: 7-9, 3-3 (NFC West) | |||
| Date/Time | Opponent | Result | Tickets |
| Sun. Sept. 7 | Lost 23-13 | --- | |
| Sun. Sept. 14 | Won 33-30 | --- | |
| Sun. Sept. 21 | Won 31-13 | --- | |
| Sun. Sept. 28 | Lost 31-17 | --- | |
| Sun. Oct. 5 | Lost 30-21 | --- | |
| Sun. Oct. 12 | Lost 40-26 | --- | |
| Sun. Oct. 19 | Lost 29-17 | --- | |
| Sun. Oct. 26 | Lost 34-13 | --- | |
| Sun. Nov. 2 | Bye Week | --- | --- |
| Mon. Nov. 10 | Lost 29-24 | --- | |
| Sun. Nov. 16 | Won 35-16 | --- | |
| Sun. Nov. 23 | Lost 35-22 | --- | |
| Sun. Nov. 30 | Won 10-3 | --- | |
| Sun. Dec. 7 | Won 24-14 | --- | |
| Sun. Dec. 14 | Lost 14-9 | --- | |
| Sun. Dec. 21 | Won 17-16 | --- | |
| Sun. Dec. 28 | Won 27-24 | --- | |