| San Francisco 49ers | ||
2009 San Francisco 49ers Football ScheduleFinal Record: 8-8, 5-1 (NFC West) | ||||
| Date | Opponent | Result | Tickets | |
| Sunday Sept. 13 | at Arizona Cardinals University of Phoenix Stadium, Glendale, AZ | Won 20-16 | --- | |
| Sunday Sept. 20 | Seattle Seahawks Candlestick Park, San Francisco, CA | Won 23-10 | --- | |
| Sunday Sept. 27 | at Minnesota Vikings Mall of America Field, Minneapolis, MN | Lost 27-24 | --- | |
| Sunday Oct. 4 | St. Louis Rams Candlestick Park, San Francisco, CA | Won 35-0 | --- | |
| Sunday Oct. 11 | Atlanta Falcons Candlestick Park, San Francisco, CA | Lost 45-10 | --- | |
| Sunday Oct. 18 | --- | BYE | --- | --- |
| Sunday Oct. 25 | at Houston Texans Reliant Stadium, Houston, TX | Lost 24-21 | --- | |
| Sunday Nov. 1 | at Indianapolis Colts Lucas Oil Stadium, Indianapolis, IN | Lost 18-14 | --- | |
| Sunday Nov. 8 | Tennessee Titans Candlestick Park, San Francisco, CA | Lost 34-27 | --- | |
| Thursday Nov. 12 | Chicago Bears Candlestick Park, San Francisco, CA | Won 10-6 | --- | |
| Sunday Nov. 22 | at Green Bay Packers Lambeau Field, Green Bay, WI | Lost 30-24 | --- | |
| Sunday Nov. 29 | Jacksonville Jaguars Candlestick Park, San Francisco, CA | Won 20-3 | --- | |
| Sunday Dec. 6 | at Seattle Seahawks Qwest Field, Seattle, WA | Lost 20-17 | --- | |
| Monday Dec. 14 | Arizona Cardinals Candlestick Park, San Francisco, CA | Won 24-9 | --- | |
| Sunday Dec. 20 | at Philadelphia Eagles Lincoln Financial Field, Philadelphia, PA | Lost 27-13 | --- | |
| Sunday Dec. 27 | Detroit Lions Candlestick Park, San Francisco, CA | Won 20-6 | --- | |
| Sunday Jan. 3 | at St. Louis Rams Edward Jones Dome, St. Louis, MO | Won 28-6 | --- | |