 | Buffalo Bills | |
2010 Buffalo Bills Football ScheduleFinal Record: 4-12, 1-5 (AFC East) | ||||
| Date | Opponent | Result | Tickets | |
| Sunday Sept. 12 |  | Miami Dolphins Ralph Wilson Stadium, Orchard Park, NY | Lost 15-10 | --- |
| Sunday Sept. 19 |  | at Green Bay Packers Lambeau Field, Green Bay, WI | Lost 34-7 | --- |
| Sunday Sept. 26 |  | at New England Patriots Gillette Stadium, Foxborough, MA | Lost 38-30 | --- |
| Sunday Oct. 3 |  | New York Jets Ralph Wilson Stadium, Orchard Park, NY | Lost 38-14 | --- |
| Sunday Oct. 10 |  | Jacksonville Jaguars Ralph Wilson Stadium, Orchard Park, NY | Lost 36-26 | --- |
| Sunday Oct. 17 | --- | BYE | --- | --- |
| Sunday Oct. 24 |  | at Baltimore Ravens M&T Bank Stadium, Baltimore, MD | Lost 37-34 (OT) | --- |
| Sunday Oct. 31 |  | at Kansas City Chiefs Arrowhead Stadium, Kansas City, MO | Lost 13-10 (OT) | --- |
| Sunday Nov. 7 |  | Chicago Bears Rogers Centre, Toronto, Canada | Lost 22-19 | --- |
| Sunday Nov. 14 |  | Detroit Lions Ralph Wilson Stadium, Orchard Park, NY | Won 14-12 | --- |
| Sunday Nov. 21 |  | at Cincinnati Bengals Paul Brown Stadium, Cincinnati, OH | Won 49-31 | --- |
| Sunday Nov. 28 |  | Pittsburgh Steelers Ralph Wilson Stadium, Orchard Park, NY | Lost 19-16 (OT) | --- |
| Sunday Dec. 5 |  | at Minnesota Vikings Mall of America Field, Minneapolis, MN | Lost 38-14 | --- |
| Sunday Dec. 12 |  | Cleveland Browns Ralph Wilson Stadium, Orchard Park, NY | Won 13-6 | --- |
| Sunday Dec. 19 | | at Miami Dolphins Sun Life Stadium, Miami Gardens, FL | Won 17-14 | --- |
| Sunday Dec. 26 | | New England Patriots Ralph Wilson Stadium, Orchard Park, NY | Lost 34-3 | --- |
| Sunday Jan. 2 | | at New York Jets MetLife Stadium, East Rutherford, NJ | Lost 38-7 | --- |
