 | Buffalo Bills | |
2010 Buffalo Bills Football ScheduleFinal Record: 4-12, 1-5 (AFC East) | |||
| Date/Time | Opponent | Result | Tickets |
| Sun. Sept. 12 1:00 p.m. ET |  Miami Dolphins | Lost 15-10 | --- |
| Sun. Sept. 19 1:00 p.m. ET |  at Green Bay Packers | Lost 34-7 | --- |
| Sun. Sept. 26 1:00 p.m. ET |  at New England Patriots | Lost 38-30 | --- |
| Sun. Oct. 3 1:00 p.m. ET |  New York Jets | Lost 38-14 | --- |
| Sun. Oct. 10 1:00 p.m. ET |  Jacksonville Jaguars | Lost 36-26 | --- |
| Sun. Oct. 17 | Bye Week | --- | --- |
| Sun. Oct. 24 1:00 p.m. ET |  at Baltimore Ravens | Lost 37-34 (OT) | --- |
| Sun. Oct. 31 1:00 p.m. ET |  at Kansas City Chiefs | Lost 13-10 (OT) | --- |
| Sun. Nov. 7 1:00 p.m. ET |  Chicago Bears 1 | Lost 22-19 | --- |
| Sun. Nov. 14 1:00 p.m. ET |  Detroit Lions | Won 14-12 | --- |
| Sun. Nov. 21 1:00 p.m. ET |  at Cincinnati Bengals | Won 49-31 | --- |
| Sun. Nov. 28 1:00 p.m. ET |  Pittsburgh Steelers | Lost 19-16 (OT) | --- |
| Sun. Dec. 5 1:00 p.m. ET |  at Minnesota Vikings | Lost 38-14 | --- |
| Sun. Dec. 12 1:00 p.m. ET |  Cleveland Browns | Won 13-6 | --- |
| Sun. Dec. 19 1:00 p.m. ET | at Miami Dolphins | Won 17-14 | --- |
| Sun. Dec. 26 1:00 p.m. ET | New England Patriots | Lost 34-3 | --- |
| Sun. Jan. 2 1:00 p.m. ET | at New York Jets | Lost 38-7 | --- |
| at Toronto, ON Canada (Rogers Centre) | |||
