| Denver Broncos | ||
2010 Denver Broncos Football ScheduleFinal Record: 4-12, 1-5 (AFC West) | ||||
| Date | Opponent | Result | Tickets | |
| Sunday Sept. 12 | at Jacksonville Jaguars EverBank Field, Jacksonville, FL | Lost 24-17 | --- | |
| Sunday Sept. 19 | Seattle Seahawks Invesco Field at Mile High, Denver, CO | Won 31-14 | --- | |
| Sunday Sept. 26 | Indianapolis Colts Invesco Field at Mile High, Denver, CO | Lost 27-13 | --- | |
| Sunday Oct. 3 | at Tennessee Titans LP Field, Nashville, TN | Won 26-20 | --- | |
| Sunday Oct. 10 | at Baltimore Ravens M&T Bank Stadium, Baltimore, MD | Lost 31-17 | --- | |
| Sunday Oct. 17 | New York Jets Invesco Field at Mile High, Denver, CO | Lost 24-20 | --- | |
| Sunday Oct. 24 | Oakland Raiders Invesco Field at Mile High, Denver, CO | Lost 59-14 | --- | |
| Sunday Oct. 31 | at San Francisco 49ers Wembley Stadium, London, England, UK | Lost 24-16 | --- | |
| Sunday Nov. 7 | --- | BYE | --- | --- |
| Sunday Nov. 14 | Kansas City Chiefs Invesco Field at Mile High, Denver, CO | Won 49-29 | --- | |
| Monday Nov. 22 | at San Diego Chargers Qualcomm Stadium, San Diego, CA | Lost 35-14 | --- | |
| Sunday Nov. 28 | St. Louis Rams Invesco Field at Mile High, Denver, CO | Lost 36-33 | --- | |
| Sunday Dec. 5 | at Kansas City Chiefs Arrowhead Stadium, Kansas City, MO | Lost 10-6 | --- | |
| Sunday Dec. 12 | at Arizona Cardinals University of Phoenix Stadium, Glendale, AZ | Lost 43-13 | --- | |
| Sunday Dec. 19 | at Oakland Raiders Oakland–Alameda County Coliseum, Oakland, CA | Lost 39-23 | --- | |
| Sunday Dec. 26 | Houston Texans Invesco Field at Mile High, Denver, CO | Won 24-23 | --- | |
| Sunday Jan. 2 | San Diego Chargers Invesco Field at Mile High, Denver, CO | Lost 33-28 | --- | |