 | Detroit Lions | |
2010 Detroit Lions Football ScheduleFinal Record: 6-10, 2-4 (NFC North) | |||
| Date/Time | Opponent | Result | Tickets |
| Sun. Sept. 12 1:00 p.m. ET |  at Chicago Bears | Lost 19-14 | --- |
| Sun. Sept. 19 1:00 p.m. ET |  Philadelphia Eagles | Lost 35-32 | --- |
| Sun. Sept. 26 1:00 p.m. ET |  at Minnesota Vikings | Lost 24-10 | --- |
| Sun. Oct. 3 1:00 p.m. ET |  at Green Bay Packers | Lost 28-26 | --- |
| Sun. Oct. 10 1:00 p.m. ET |  St. Louis Rams | Won 44-6 | --- |
| Sun. Oct. 17 1:00 p.m. ET |  at New York Giants | Lost 28-20 | --- |
| Sun. Oct. 24 | Bye Week | --- | --- |
| Sun. Oct. 31 1:00 p.m. ET |  Washington Redskins | Won 37-25 | --- |
| Sun. Nov. 7 1:00 p.m. ET |  New York Jets | Lost 23-20 (OT) | --- |
| Sun. Nov. 14 1:00 p.m. ET |  at Buffalo Bills | Lost 14-12 | --- |
| Sun. Nov. 21 1:00 p.m. ET |  at Dallas Cowboys | Lost 35-19 | --- |
| Thu. Nov. 25 12:30 p.m. ET |  New England Patriots | Lost 45-24 | --- |
| Sat. Dec. 5 12:30 p.m. ET | Chicago Bears | Lost 24-20 | --- |
| Sun. Dec. 12 1:00 p.m. ET | Green Bay Packers | Won 7-3 | --- |
| Sun. Dec. 19 1:00 p.m. ET |  at Tampa Bay Buccaneers | Won 23-20 (OT) | --- |
| Sun. Dec. 26 1:00 p.m. ET |  at Miami Dolphins | Won 34-27 | --- |
| Sun. Jan. 2 1:00 p.m. ET | Minnesota Vikings | Won 20-13 | --- |
