 | Detroit Lions | |
2010 Detroit Lions Football ScheduleFinal Record: 6-10, 2-4 (NFC North) | ||||
| Date | Opponent | Result | Tickets | |
| Sunday Sept. 12 |  | at Chicago Bears Soldier Field, Chicago, IL | Lost 19-14 | --- |
| Sunday Sept. 19 |  | Philadelphia Eagles Ford Field, Detroit, MI | Lost 35-32 | --- |
| Sunday Sept. 26 |  | at Minnesota Vikings Mall of America Field, Minneapolis, MN | Lost 24-10 | --- |
| Sunday Oct. 3 |  | at Green Bay Packers Lambeau Field, Green Bay, WI | Lost 28-26 | --- |
| Sunday Oct. 10 |  | St. Louis Rams Ford Field, Detroit, MI | Won 44-6 | --- |
| Sunday Oct. 17 |  | at New York Giants MetLife Stadium, East Rutherford, NJ | Lost 28-20 | --- |
| Sunday Oct. 24 | --- | BYE | --- | --- |
| Sunday Oct. 31 |  | Washington Redskins Ford Field, Detroit, MI | Won 37-25 | --- |
| Sunday Nov. 7 |  | New York Jets Ford Field, Detroit, MI | Lost 23-20 (OT) | --- |
| Sunday Nov. 14 |  | at Buffalo Bills Ralph Wilson Stadium, Orchard Park, NY | Lost 14-12 | --- |
| Sunday Nov. 21 |  | at Dallas Cowboys Cowboys Stadium, Arlington, TX | Lost 35-19 | --- |
| Thursday Nov. 25 |  | New England Patriots Ford Field, Detroit, MI | Lost 45-24 | --- |
| Saturday Dec. 5 | | Chicago Bears Ford Field, Detroit, MI | Lost 24-20 | --- |
| Sunday Dec. 12 | | Green Bay Packers Ford Field, Detroit, MI | Won 7-3 | --- |
| Sunday Dec. 19 |  | at Tampa Bay Buccaneers Raymond James Stadium, Tampa Bay, FL | Won 23-20 (OT) | --- |
| Sunday Dec. 26 |  | at Miami Dolphins Sun Life Stadium, Miami Gardens, FL | Won 34-27 | --- |
| Sunday Jan. 2 | | Minnesota Vikings Ford Field, Detroit, MI | Won 20-13 | --- |
