| Detroit Lions | ||
2010 Detroit Lions Football ScheduleFinal Record: 6-10, 2-4 (NFC North) | ||||
| Date | Opponent | Result | Tickets | |
| Sunday Sept. 12 | at Chicago Bears Soldier Field, Chicago, IL | Lost 19-14 | --- | |
| Sunday Sept. 19 | Philadelphia Eagles Ford Field, Detroit, MI | Lost 35-32 | --- | |
| Sunday Sept. 26 | at Minnesota Vikings Mall of America Field, Minneapolis, MN | Lost 24-10 | --- | |
| Sunday Oct. 3 | at Green Bay Packers Lambeau Field, Green Bay, WI | Lost 28-26 | --- | |
| Sunday Oct. 10 | St. Louis Rams Ford Field, Detroit, MI | Won 44-6 | --- | |
| Sunday Oct. 17 | at New York Giants MetLife Stadium, East Rutherford, NJ | Lost 28-20 | --- | |
| Sunday Oct. 24 | --- | BYE | --- | --- |
| Sunday Oct. 31 | Washington Redskins Ford Field, Detroit, MI | Won 37-25 | --- | |
| Sunday Nov. 7 | New York Jets Ford Field, Detroit, MI | Lost 23-20 (OT) | --- | |
| Sunday Nov. 14 | at Buffalo Bills Ralph Wilson Stadium, Orchard Park, NY | Lost 14-12 | --- | |
| Sunday Nov. 21 | at Dallas Cowboys Cowboys Stadium, Arlington, TX | Lost 35-19 | --- | |
| Thursday Nov. 25 | New England Patriots Ford Field, Detroit, MI | Lost 45-24 | --- | |
| Saturday Dec. 5 | Chicago Bears Ford Field, Detroit, MI | Lost 24-20 | --- | |
| Sunday Dec. 12 | Green Bay Packers Ford Field, Detroit, MI | Won 7-3 | --- | |
| Sunday Dec. 19 | at Tampa Bay Buccaneers Raymond James Stadium, Tampa Bay, FL | Won 23-20 (OT) | --- | |
| Sunday Dec. 26 | at Miami Dolphins Sun Life Stadium, Miami Gardens, FL | Won 34-27 | --- | |
| Sunday Jan. 2 | Minnesota Vikings Ford Field, Detroit, MI | Won 20-13 | --- | |