 | Indianapolis Colts | |
2010 Indianapolis Colts Football ScheduleFinal Record: 10-7, 4-2 (AFC South) | |||
| Date/Time | Opponent | Result | Tickets |
| Sun. Sept. 12 1:00 p.m. ET |  at Houston Texans | Lost 34-24 | --- |
| Sun. Sept. 19 8:20 p.m. ET |  New York Giants | Won 38-14 | --- |
| Sun. Sept. 26 4:15 p.m. ET |  at Denver Broncos | Won 27-13 | --- |
| Sun. Oct. 3 4:05 p.m. ET |  at Jacksonville Jaguars | Lost 31-28 | --- |
| Sun. Oct. 10 1:00 p.m. ET |  Kansas City Chiefs | Won 19-9 | --- |
| Sun. Oct. 17 8:20 p.m. ET |  at Washington Redskins | Won 27-24 | --- |
| Sun. Oct. 24 | Bye Week | --- | --- |
| Mon. Nov. 1 8:30 p.m. ET | Houston Texans | Won 30-17 | --- |
| Sun. Nov. 7 4:15 p.m. ET |  at Philadelphia Eagles | Lost 26-24 | --- |
| Sun. Nov. 14 1:00 p.m. ET |  Cincinnati Bengals | Won 23-17 | --- |
| Sun. Nov. 21 4:15 p.m. ET |  at New England Patriots | Lost 31-28 | --- |
| Sun. Nov. 28 8:20 p.m. ET |  San Diego Chargers | Lost 36-14 | --- |
| Sun. Dec. 5 4:15 p.m. ET |  Dallas Cowboys | Lost 38-35 (OT) | --- |
| Thu. Dec. 9 8:20 p.m. ET |  at Tennessee Titans | Won 30-28 | --- |
| Sun. Dec. 19 1:00 p.m. ET | Jacksonville Jaguars | Won 34-24 | --- |
| Sun. Dec. 26 4:05 p.m. ET |  at Oakland Raiders | Won 31-26 | --- |
| Sun. Jan. 2 1:00 p.m. ET | Tennessee Titans | Won 23-20 | --- |
| 2010 AFC Playoffs - Wild Card Round | |||
| Sat. Jan. 8 8:00 p.m. ET |  New York Jets | Lost 17-16 | --- |
