| Jacksonville Jaguars | ||
2010 Jacksonville Jaguars Football ScheduleFinal Record: 8-8, 3-3 (AFC South) | ||||
| Date | Opponent | Result | Tickets | |
| Sunday Sept. 12 | Denver Broncos EverBank Field, Jacksonville, FL | Won 24-17 | --- | |
| Sunday Sept. 19 | at San Diego Chargers Qualcomm Stadium, San Diego, CA | Lost 38-13 | --- | |
| Sunday Sept. 26 | Philadelphia Eagles EverBank Field, Jacksonville, FL | Lost 28-3 | --- | |
| Sunday Oct. 3 | Indianapolis Colts EverBank Field, Jacksonville, FL | Won 31-28 | --- | |
| Sunday Oct. 10 | at Buffalo Bills Ralph Wilson Stadium, Orchard Park, NY | Won 36-26 | --- | |
| Monday Oct. 18 | Tennessee Titans EverBank Field, Jacksonville, FL | Lost 30-3 | --- | |
| Sunday Oct. 24 | at Kansas City Chiefs Arrowhead Stadium, Kansas City, MO | Lost 42-20 | --- | |
| Sunday Oct. 31 | at Dallas Cowboys Cowboys Stadium, Arlington, TX | Won 35-17 | --- | |
| Sunday Nov. 7 | --- | BYE | --- | --- |
| Sunday Nov. 14 | Houston Texans EverBank Field, Jacksonville, FL | Won 31-24 | --- | |
| Sunday Nov. 21 | Cleveland Browns EverBank Field, Jacksonville, FL | Won 24-20 | --- | |
| Sunday Nov. 28 | at New York Giants MetLife Stadium, East Rutherford, NJ | Lost 24-20 | --- | |
| Sunday Dec. 5 | at Tennessee Titans LP Field, Nashville, TN | Won 17-6 | --- | |
| Sunday Dec. 12 | Oakland Raiders EverBank Field, Jacksonville, FL | Won 38-31 | --- | |
| Sunday Dec. 19 | at Indianapolis Colts Lucas Oil Stadium, Indianapolis, IN | Lost 34-24 | --- | |
| Sunday Dec. 26 | Washington Redskins EverBank Field, Jacksonville, FL | Lost 20-17 (OT) | --- | |
| Sunday Jan. 2 | at Houston Texans Reliant Stadium, Houston, TX | Lost 34-17 | --- | |