 | Jacksonville Jaguars | |
2010 Jacksonville Jaguars Football ScheduleFinal Record: 8-8, 3-3 (AFC South) | ||||
| Date | Opponent | Result | Tickets | |
| Sunday Sept. 12 |  | Denver Broncos EverBank Field, Jacksonville, FL | Won 24-17 | --- |
| Sunday Sept. 19 |  | at San Diego Chargers Qualcomm Stadium, San Diego, CA | Lost 38-13 | --- |
| Sunday Sept. 26 |  | Philadelphia Eagles EverBank Field, Jacksonville, FL | Lost 28-3 | --- |
| Sunday Oct. 3 |  | Indianapolis Colts EverBank Field, Jacksonville, FL | Won 31-28 | --- |
| Sunday Oct. 10 |  | at Buffalo Bills Ralph Wilson Stadium, Orchard Park, NY | Won 36-26 | --- |
| Monday Oct. 18 |  | Tennessee Titans EverBank Field, Jacksonville, FL | Lost 30-3 | --- |
| Sunday Oct. 24 |  | at Kansas City Chiefs Arrowhead Stadium, Kansas City, MO | Lost 42-20 | --- |
| Sunday Oct. 31 |  | at Dallas Cowboys Cowboys Stadium, Arlington, TX | Won 35-17 | --- |
| Sunday Nov. 7 | --- | BYE | --- | --- |
| Sunday Nov. 14 |  | Houston Texans EverBank Field, Jacksonville, FL | Won 31-24 | --- |
| Sunday Nov. 21 |  | Cleveland Browns EverBank Field, Jacksonville, FL | Won 24-20 | --- |
| Sunday Nov. 28 |  | at New York Giants MetLife Stadium, East Rutherford, NJ | Lost 24-20 | --- |
| Sunday Dec. 5 | | at Tennessee Titans LP Field, Nashville, TN | Won 17-6 | --- |
| Sunday Dec. 12 |  | Oakland Raiders EverBank Field, Jacksonville, FL | Won 38-31 | --- |
| Sunday Dec. 19 | | at Indianapolis Colts Lucas Oil Stadium, Indianapolis, IN | Lost 34-24 | --- |
| Sunday Dec. 26 |  | Washington Redskins EverBank Field, Jacksonville, FL | Lost 20-17 (OT) | --- |
| Sunday Jan. 2 | | at Houston Texans Reliant Stadium, Houston, TX | Lost 34-17 | --- |
