 | San Diego Chargers | |
2010 San Diego Chargers Football ScheduleFinal Record: 9-7, 3-3 (AFC West) | ||||
| Date | Opponent | Result | Tickets | |
| Monday Sept. 13 |  | at Kansas City Chiefs Arrowhead Stadium, Kansas City, MO | Lost 21-14 | --- |
| Sunday Sept. 19 |  | Jacksonville Jaguars Qualcomm Stadium, San Diego, CA | Won 38-13 | --- |
| Sunday Sept. 26 |  | at Seattle Seahawks Qwest Field, Seattle, WA | Lost 27-20 | --- |
| Sunday Oct. 3 |  | Arizona Cardinals Qualcomm Stadium, San Diego, CA | Won 41-10 | --- |
| Sunday Oct. 10 |  | at Oakland Raiders Oakland–Alameda County Coliseum, Oakland, CA | Lost 35-27 | --- |
| Sunday Oct. 17 |  | at St. Louis Rams Edward Jones Dome, St. Louis, MO | Lost 20-17 | --- |
| Sunday Oct. 24 |  | New England Patriots Qualcomm Stadium, San Diego, CA | Lost 23-20 | --- |
| Sunday Oct. 31 |  | Tennessee Titans Qualcomm Stadium, San Diego, CA | Won 33-25 | --- |
| Sunday Nov. 7 |  | at Houston Texans Reliant Stadium, Houston, TX | Won 29-23 | --- |
| Sunday Nov. 14 | --- | BYE | --- | --- |
| Monday Nov. 22 |  | Denver Broncos Qualcomm Stadium, San Diego, CA | Won 35-14 | --- |
| Sunday Nov. 28 |  | at Indianapolis Colts Lucas Oil Stadium, Indianapolis, IN | Won 36-14 | --- |
| Sunday Dec. 5 | | Oakland Raiders Qualcomm Stadium, San Diego, CA | Lost 28-13 | --- |
| Sunday Dec. 12 | | Kansas City Chiefs Qualcomm Stadium, San Diego, CA | Won 31-0 | --- |
| Thursday Dec. 16 |  | San Francisco 49ers Qualcomm Stadium, San Diego, CA | Won 34-7 | --- |
| Sunday Dec. 26 |  | at Cincinnati Bengals Paul Brown Stadium, Cincinnati, OH | Lost 34-20 | --- |
| Sunday Jan. 2 | | at Denver Broncos Invesco Field at Mile High, Denver, CO | Won 33-28 | --- |
