 | San Francisco 49ers | |
2010 San Francisco 49ers Football ScheduleFinal Record: 6-10, 4-2 (NFC West) | |||
| Date/Time | Opponent | Result | Tickets |
| Sun. Sept. 12 4:15 p.m. ET |  at Seattle Seahawks | Lost 31-6 | --- |
| Mon. Sept. 20 8:30 p.m. ET |  New Orleans Saints | Lost 25-22 | --- |
| Sun. Sept. 26 1:00 p.m. ET |  at Kansas City Chiefs | Lost 31-10 | --- |
| Sun. Oct. 3 1:00 p.m. ET |  at Atlanta Falcons | Lost 16-14 | --- |
| Sun. Oct. 10 8:20 p.m. ET |  Philadelphia Eagles | Lost 27-24 | --- |
| Sun. Oct. 17 4:05 p.m. ET |  Oakland Raiders | Won 17-9 | --- |
| Sun. Oct. 24 1:00 p.m. ET |  at Carolina Panthers | Lost 23-20 | --- |
| Sun. Oct. 31 1:00 p.m. ET |  Denver Broncos 1 | Won 24-16 | --- |
| Sun. Nov. 7 | Bye Week | --- | --- |
| Sun. Nov. 14 4:15 p.m. ET |  St. Louis Rams | Won 23-20 (OT) | --- |
| Sun. Nov. 21 4:05 p.m. ET |  Tampa Bay Buccaneers | Lost 21-0 | --- |
| Mon. Nov. 29 8:30 p.m. ET |  at Arizona Cardinals | Won 27-6 | --- |
| Sun. Dec. 5 1:00 p.m. ET |  at Green Bay Packers | Lost 34-16 | --- |
| Sun. Dec. 12 4:05 p.m. ET | Seattle Seahawks | Won 40-21 | --- |
| Thu. Dec. 16 8:20 p.m. ET |  at San Diego Chargers | Lost 34-7 | --- |
| Sun. Dec. 26 1:00 p.m. ET | at St. Louis Rams | Lost 25-17 | --- |
| Sun. Jan. 2 4:15 p.m. ET | Arizona Cardinals | Won 38-7 | --- |
| 1 at London, United Kingdom (Wembley Stadium) | |||
