| Detroit Lions | ||
2012 Detroit Lions Football Schedule | ||||
| Date | Opponent | Time/TV | Tickets | |
| Sunday Sept. 9 | St. Louis Rams Ford Field, Detroit, MI | Won 27-23 | --- | |
| Sunday Sept. 16 | at San Francisco 49ers Candlestick Park, San Francisco, CA | Lost 27-19 | --- | |
| Sunday Sept. 23 | at Tennessee Titans LP Field, Nashville, TN | Lost 44-41 (OT) | --- | |
| Sunday Sept. 30 | Minnesota Vikings Ford Field, Detroit, MI | Lost 20-13 | --- | |
| Sunday Oct. 7 | --- | BYE | --- | --- |
| Sunday Oct. 14 | at Philadelphia Eagles Lincoln Financial Field, Philadelphia, PA | Won 26-23 (OT) | --- | |
| Monday Oct. 22 | at Chicago Bears Soldier Field, Chicago, IL | Lost 13-7 | --- | |
| Sunday Oct. 28 | Seattle Seahawks Ford Field, Detroit, MI | Won 28-24 | --- | |
| Sunday Nov. 4 | at Jacksonville Jaguars EverBank Field, Jacksonville, FL | Won 31-14 | --- | |
| Sunday Nov. 11 | at Minnesota Vikings Mall of America Field, Minneapolis, MN | Lost 34-24 | --- | |
| Sunday Nov. 18 | Green Bay Packers Ford Field, Detroit, MI | Lost 24-20 | --- | |
| Thursday Nov. 22 | Houston Texans Ford Field, Detroit, MI | Lost 34-31 (OT) | --- | |
| Sunday Dec. 2 | Indianapolis Colts Ford Field, Detroit, MI | Lost 35-33 | --- | |
| Sunday Dec. 9 | at Green Bay Packers Lambeau Field, Green Bay, WI | Lost 27-20 | --- | |
| Sunday Dec. 16 | at Arizona Cardinals University of Phoenix Stadium, Glendale, AZ | Lost 38-10 | --- | |
| Saturday Dec. 22 | Atlanta Falcons Ford Field, Detroit, MI | Lost 31-18 | --- | |
| Sunday Dec. 30 | Chicago Bears Ford Field, Detroit, MI | Lost 26-24 | --- | |