| San Diego Chargers | ||
2012 San Diego Chargers Football Schedule | ||||
| Date | Opponent | Time/TV | Tickets | |
| Monday Sept. 10 | at Oakland Raiders O.co Coliseum, Oakland, CA | Won 22-14 | --- | |
| Sunday Sept. 16 | Tennessee Titans Qualcomm Stadium, San Diego, CA | Won 38-10 | --- | |
| Sunday Sept. 23 | Atlanta Falcons Qualcomm Stadium, San Diego, CA | Lost 27-3 | --- | |
| Sunday Sept. 30 | at Kansas City Chiefs Arrowhead Stadium, Kansas City, MO | Won 37-20 | --- | |
| Sunday Oct. 7 | at New Orleans Saints Mercedes-Benz Superdome, New Orleans, LA | Lost 31-24 | --- | |
| Monday Oct. 15 | Denver Broncos Qualcomm Stadium, San Diego, CA | Lost 35-24 | --- | |
| Sunday Oct. 21 | --- | BYE | --- | --- |
| Sunday Oct. 28 | at Cleveland Browns Cleveland Browns Stadium, Cleveland, OH | Lost 7-6 | --- | |
| Thursday Nov. 1 | Kansas City Chiefs Qualcomm Stadium, San Diego, CA | Won 31-13 | --- | |
| Sunday Nov. 11 | at Tampa Bay Buccaneers Raymond James Stadium, Tampa Bay, FL | Lost 34-24 | --- | |
| Sunday Nov. 18 | at Denver Broncos Sports Authority Field at Mile High, Denver, CO | Lost 30-23 | --- | |
| Sunday Nov. 25 | Baltimore Ravens Qualcomm Stadium, San Diego, CA | Lost 16-13 (OT) | --- | |
| Sunday Dec. 2 | Cincinnati Bengals Qualcomm Stadium, San Diego, CA | Lost 20-13 | --- | |
| Sunday Dec. 9 | at Pittsburgh Steelers Heinz Field, Pittsburgh, PA | Won 34-24 | --- | |
| Sunday Dec. 16 | Carolina Panthers Qualcomm Stadium, San Diego, CA | Lost 31-7 | --- | |
| Sunday Dec. 23 | at New York Jets MetLife Stadium, East Rutherford, NJ | Won 27-17 | --- | |
| Sunday Dec. 30 | Oakland Raiders Qualcomm Stadium, San Diego, CA | Won 24-21 | --- | |